OTX015 for cell activation

Catalog number
2651-1
Name
OTX015 for cell activation
Size
1 mg
Price
175.00 EUR
Supplier

Details

Description
OTX015 is a potent inhibitor of BRD2, BRD3, and BRD4 (EC₅₀s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.
Peptide sequence
N/A
CAS number
202590-98-5
Molecular weight
492
Category
Biochemicals
Other name
(6S)-​4-​(4-​chlorophenyl)-​N-​(4-​hydroxyphenyl)-​2,​3,​9-​trimethyl-​6H-​thieno[3,​2-​f][1,​2,​4]triazolo[4,​3-​a][1,​4]diazepine-​6-​acetamide; HY-15743
Molecular formula
C₂₅H₂₂ClN₅O₂S
Physical appearance
Crystaline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (~25 mg/ml) or EtOH (~ 25 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.