CID-755673 for cell activation

CID-755673 is a selective small molecule inhibitor of protein kinase D (PKD) (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively). It exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC₅₀s range from 15 to > 50 µM). At 25 µM, CID-755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.

N/A

521937-07-5

217.22

Biochemicals

 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one

C₁₂H₁₁NO₃

Brown solid

N/A

No

Yes

≥98% by HPLC

DMSO (>20 mg/ml) or EtOH (~ 5 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.