CH-223191 for cell activation

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It blocks activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (IC₅₀ = 0.03 µM). It also blocks TCDD-mediated translocation and DNA-binding activity of the AhR. Displays no AhR agonist activity (at concentrations up to 100 μM). Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes.

N/A

301326-22-7

333.39

Biochemicals

 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

C₁₉H₁₉N₅O

Orange solid

N/A

No

Yes

³95%

DMSO (>30 mg/ml) or EtOH (~3 mg/ml)

-20°C

Gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.