HC Toxin for cell activation
Catalog number
2728-500
Name
HC Toxin for cell activation
Size
500 µg
Price
229.00 EUR
Supplier
Details
Description
HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells
Peptide sequence
N/A
CAS number
83209-65-8
Molecular weight
436.5
Category
Biochemicals
Other name
(6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone; Toxin I (Helminthosporium carbonum)
Molecular formula
C₂₁H₃₂N₄O₆
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥95%
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
