AAL-993 for cell activation

Catalog number
2740-10
Name
AAL-993 for cell activation
Size
10 mg
Price
414.00 EUR
Supplier

Details

Description
AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model).
Peptide sequence
N/A
CAS number
269390-77-4
Molecular weight
371.36
Category
Biochemicals
Other name
2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
Molecular formula
C₂₀H₁₆F₃N₃O
Physical appearance
Light yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (>25 mg/ml) or EtOH (~15 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.