AAL-993 for cell activation

AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model).

N/A

269390-77-4

371.36

Biochemicals

2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide

C₂₀H₁₆F₃N₃O

Light yellow solid

N/A

No

Yes

≥98% by TLC

DMSO (>25 mg/ml) or EtOH (~15 mg/ml)

-20°C

Gel Pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.