CUR-61414 for cell activation
Catalog number
2743-25
Name
CUR-61414 for cell activation
Size
25 mg
Price
588.00 EUR
Supplier
Details
Description
CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.
Peptide sequence
N/A
CAS number
334998-36-6
Molecular weight
550.69
Category
Biochemicals
Other name
N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Molecular formula
C₃₁H₄₂N₄O₅
Physical appearance
Tan solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by TLC
Reconstitute instructions
DMSO (40 mg/ml) or EtOH (20 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
