Filipin III for cell activation
Catalog number
2744-500
Name
Filipin III for cell activation
Size
500 µg
Price
197.00 EUR
Supplier
Details
Description
Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to cholesterol forming a fluorescent complex which may be used for staining. Filipin III disrupts the lipid raft/caveolae endocytosis pathway. Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.
Peptide sequence
N/A
CAS number
480-49-9
Molecular weight
654.8
Category
Biochemicals
Other name
4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,21E,23E,25E-pentaen-2-one
Molecular formula
C₃₅H₅₈O₁₁
Physical appearance
Tan solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥85% by HPLC
Reconstitute instructions
DMSO (5 mg/ml) or EtOH (2 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
