IDO1 Inhibitor I for cell activation

IDO1 Inhibitor I is a potent IDO1 inhibitor that displays IC₅₀ values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan 2,3-dioxygenase (IC₅₀ > 10 µM).

N/A

914471-09-3

271.63

Biochemicals

4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

C₉H₇ClFN₅O₂

White solid

N/A

No

Yes

≥98% by HPLC

DMSO (>25 mg/ml)

-20°C

Gel Pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.