GSK-J1 (Free acid) for cell activation

GSK-J1 is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available (Cat. Nos. 2259 & 2762).

N/A

1373422-53-7

398.45

Biochemicals

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine

C₂₂H₂₃N₅O₂

Pale yellow solid

N/A

No

Y

≥98% by TLC

DMSO (~ 20 mg/ml)

-20°C

Gel Pack

36 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.