GSK-J4 (Free base) for cell activation

Catalog number
2762-1
Name
GSK-J4 (Free base) for cell activation
Size
1 mg
Price
121.00 EUR
Supplier

Details

Description
GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
Peptide sequence
N/A
CAS number
1373423-53-0
Molecular weight
417.50
Category
Biochemicals
Other name
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Molecular formula
C₂₄H₂₇N₅O₂
Physical appearance
Yellow waxy solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Y
Purification
≥99% by TLC
Reconstitute instructions
DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.