GSK-J4 (Free base) for cell activation

GSK- J4 is cell-permeable ethyl ester of GSK-J1 (Cat. Nos. 2260 & 2761). Acts as a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC₅₀ = 9 μM for the inhibition of TNFα release). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.

N/A

1373423-53-0

417.50

Biochemicals

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester

C₂₄H₂₇N₅O₂

Yellow waxy solid

N/A

No

Y

≥99% by TLC

DMSO (~ 40 mg/ml) or EtOH (~ 40 mg/ml)

-20°C

Gel Pack

36 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.