SF1670 for cell activation

SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.

N/A

345630-40-2

307.34

Biochemicals

N-​(9,​10-​dihydro-​9,​10-​dioxo-​2-​phenanthrenyl)-​2,​2-​dimethyl-​propanamide

C₁₉H₁₇NO₃

Light pink to dark purple solid

N/A

No

Y

≥98%

DMSO (~ 10 mg/ml)

-20°C

Gel Pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.