Apoptosis activator 2 for cell activation
Catalog number
2784-25
Name
Apoptosis activator 2 for cell activation
Size
25 mg
Price
414.00 EUR
Supplier
Details
Description
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
Peptide sequence
N/A
CAS number
79183-19-0
Molecular weight
306.14
Category
Biochemicals
Other name
1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Molecular formula
C₁₅H₉Cl₂NO₂
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Y
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 30 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
This 1 is suited for programmed cell-death studies.For cells, cell lines and tissues in culture till half confluency.
