Gambogic acid for cell activation

Catalog number
2785-25
Name
Gambogic acid for cell activation
Size
25 mg
Price
545.00 EUR
Supplier

Details

Description
Gambogic acid is a plant-derived natural product that acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle. It causes a decrease of Bcl-2 gene and an increase in Bax gene expression, which may result in apoptosis. Gambogic also acts as an inhibitor of A1 and Bcl-2 family proteins, including Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1, and Mcl-1.
Peptide sequence
N/A
CAS number
2752-65-0
Molecular weight
628.75
Category
Biochemicals
Other name
 (Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid
Molecular formula
C₃₈H₄₄O₈
Physical appearance
Orange solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Y
Purification
≥95%
Reconstitute instructions
DMSO (>25 mg/ml) or EtOH (~20 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.