Pan-caspase inhibitor, Q-VD(OMe)-OPh for cell activation

A pan-caspase inhibitor. Q-VD(OMe)-OPh is the methyl ester derivative of the pan-caspase inhibitor Q-VD-OPh (Cat. No.1170). Esterification of the aspartic acid should enhance the cell-permeability of Q-VD(OMe)-OPh.

Q-Val-Asp(OMe)-Oph

N/A

527.52

Biochemicals

(S)-methyl 5-(2,6-difluorophenoxy)-3-((S)-3-methyl-2-(quinoline-2-carboxamido)butanamido)-4-oxopentanoate

C₂₆H₂₅F₂N₃O₆

White to off-white solid

N/A

No

Y

≥98% by HPLC

DMSO (>10 mg/ml)

-20°C

Gel Pack

36 months

Protect from air and light

cell

Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.