WS3 for cell activation

WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM (induced R7T1 proliferation). More recently, WS3 has been found to mediate proliferation of primary retinal pigment epithelial cells. After WS3 removal, the retinal cells differentiated into a functional monolayer and remained functional in vivo, preserving vision when they were transplanted into RCS rats used as a model of retinal degeneration.

N/A

1421227-52-2

569.58

Biochemicals

N-[6-[4-[[[[4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide, WS-3

C₂₈H₃₀F₃N₇O₃

White to off-white solid

N/A

No

Y

≥98% by HPLC

DMSO (~ 10 mg/ml)

-20°C

Gel Pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.