Cedrulatinib for cell activation
Catalog number
2803-5
Name
Cedrulatinib for cell activation
Size
5 mg
Price
175.00 EUR
Supplier
Details
Description
Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 is inhibited with an IC₅₀ of 0.27 μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, are inhibited with IC₅₀’s within the range of 0.11 μM to 0.57 μM.
Peptide sequence
N/A
CAS number
1198300-79-6
Molecular weight
445.54
Category
Biochemicals
Other name
4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide; PRT2070; PRT-2070; PRT 2070; PRT-062070; PRT 062070; PRT062070.
Molecular formula
C₂₀H₂₇N₇O₃S
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Y
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>40 mg/ml)
Storage condition
-20°C
Shipping condition
Gel Pack
Maximum time for storage
36 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
