AT-7519 hydrochloride for cell activation

AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of action is shown to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT-7519 causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models.

N/A

902135-91-5

418.71

Biochemicals

N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride

C₁₆H₁₈Cl₃N₅O₂

White solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

Gel Pack

36 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.