Tariquidar for cell activation

Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein (P-gp) (Kd = 5.1 nM). Tariquidar inhibits the ATPase activity of P-gp, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both. At low concentrations, Tariquidar acts selectively as an inhibitor of P-gp and as a substrate of BCRP (breast cancer resistance protein). At much higher concentrations (≥100 nM). Tariquidar acts as an inhibitor of both P-gp and BCRP.

N/A

206873-63-4

646.73

Biochemicals

N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide; XR9576, XR 9576, XR-9576,Tariquidar

C₃₈H₃₈N₄O₆

Light yellow solid

N/A

No

Yes

≥98% by HPLC

DMSO (>6 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.