VX-809 for cell activation

VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.

N/A

936727-05-8

452.41

Biochemicals

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid; Lumacaftor

C₂₄H₁₈F₂N₂O₅

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO (>90 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.