CFTR Inhibitor, GlyH-101 for cell activation

Catalog number
2863-5
Name
CFTR Inhibitor, GlyH-101 for cell activation
Size
5 mg
Price
229.00 EUR
Supplier

Details

Description
CFTR Inhibitor II, or GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). GlyH-101 binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.
Peptide sequence
N/A
CAS number
328541-79-3
Molecular weight
493.15
Category
Biochemicals
Other name
2-​[(3,​5-​dibromo-​2,​4-​dihydroxyphenyl)methylene]hydrazide N-​2-​naphthalenyl-​glycine; GlyH-101; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II
Molecular formula
C₁₉H₁₅Br₂N₃O₃
Physical appearance
Yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98%
Reconstitute instructions
DMSO (>100 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.