CFTR Inhibitor, GlyH-101 for cell activation

CFTR Inhibitor II, or GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM). GlyH-101 binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.

N/A

328541-79-3

493.15

Biochemicals

2-​[(3,​5-​dibromo-​2,​4-​dihydroxyphenyl)methylene]hydrazide N-​2-​naphthalenyl-​glycine; GlyH-101; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II

C₁₉H₁₅Br₂N₃O₃

Yellow solid

N/A

No

Yes

≥98%

DMSO (>100 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.