FTI-277 hydrochloride for cell activation
Catalog number
2874-5
Name
FTI-277 hydrochloride for cell activation
Size
5 mg
Price
175.00 EUR
Supplier
Details
Description
FTI-277 is a potent and selective farnesyltransferase (FTase) inhibitor (IC50 = 0.5 nM). It potently inhibits (IC₅₀ = 100 nM) H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 blocks constitutive activation of mitogen-activated protein kinase (MAPK) in H-RasF, but not H-RasGG, or Raf-transformed cells.
Peptide sequence
N/A
CAS number
180977-34-8
Molecular weight
484.07
Category
Biochemicals
Other name
N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester hydrochloride
Molecular formula
C₂₂H₂₉N₃O₃S₂.HCl
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
