ITD-1 for cell activation

ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC₅₀ =  0.4–0.8 µM), revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate. ITD-1 does not induce differentiation of vascular smooth muscle cells or endothelial cells.

N/A

1099644-42-4

415.52

Biochemicals

4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester

C₂₇H₂₉NO₃

Off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO (~8 mg/ml) or EtOH (~4 mg/ml with warming)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.