Quinidine Sulfate dihydrate for cell activation

Catalog number
2910-1G
Name
Quinidine Sulfate dihydrate for cell activation
Size
1 g
Price
99.00 EUR
Supplier

Details

Description
Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.
Peptide sequence
N/A
CAS number
6591-63-5
Molecular weight
782.9
Category
P-gp substrate, Biochemicals, CYP inhibitor
Other name
Conquinine; β-Quinine
Molecular formula
(C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O
Physical appearance
White to off-white powder
Supplied with
N/A
Is this a salt?
Sulfate
Is it cell-permeable?
No
Purification
≥97% by HPLC
Reconstitute instructions
DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)
Storage condition
+4°C
Shipping condition
gel pack
Maximum time for storage
12 months
Storage instructions
Protect from light and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.