Quinidine Sulfate dihydrate for cell activation

Quinidine sulfate dihydrate is a diastereomer of quinine and a Na+ channel blocker. It is also a class I antiarrhythmic drug. It is a substrate (0.05 µM in Caco-2 cells) of P-glycoprotein and can also act as an inhibitor at higher concentrations (~2 µM in Caco-2 cells). Quinidine is also an inhibitor of the cytochrome P450 enzymes 2D6/3A4, and can lead to increased blood levels of lidocaine, Beta blockers, opioids, and some anti-depressants.

N/A

6591-63-5

782.9

P-gp substrate, Biochemicals, CYP inhibitor

Conquinine; β-Quinine

(C₂₀H₂₄N₂O₂)2.H₂SO₄.2H₂O

White to off-white powder

N/A

Sulfate

No

≥97% by HPLC

DMSO (~80 mg/ml), 100% EtOH (~50 mg/ml)

+4°C

gel pack

12 months

Protect from light and moisture

cell

For cells, cell lines and tissues in culture till half confluency.