GW-3965 hydrochloride for cell activation
Catalog number
9402-5
Name
GW-3965 hydrochloride for cell activation
Size
5 mg
Price
208.00 EUR
Supplier
Details
Description
GW-3965 hydrochloride is a non-steroidal liver X receptor agonist on hLXRα and hLXRβ. GW3965 has an EC₅₀ = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC₅₀ = 190 nM and 30 nM, respectively. Up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis.
Peptide sequence
N/A
CAS number
405911-17-3
Molecular weight
618.51
Category
Biochemicals
Other name
2-(3-(3-((2-Chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)propoxy)phenyl)acetic Acid hydrochloride
Molecular formula
C₃₃H₃₁ClF₃NO₃.HCl
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>50 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
