Remodelin for cell activation
Catalog number
9411-5
Name
Remodelin for cell activation
Size
5 mg
Price
148.00 EUR
Supplier
Details
Description
Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells.
Peptide sequence
N/A
CAS number
949912-58-7
Molecular weight
282.36
Category
Biochemicals
Other name
4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
Molecular formula
C₁₅H₁₄N₄S
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~ 15 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
