NKH477 for cell activation

NKH477 is a water-soluble analog of the adenylyl cyclase activator Forskolin (Cat. No. 1531). Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases. It stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms. NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.

N/A

138605-00-2

546.1

Biochemicals

N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride; Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride

C₂₇H₄₃NO₈.HCl

White solid

N/A

No

Yes

≥95%

DMSO (>50 mg/ml) or H2O (~20 mg/ml)

-20°C

gel pack

36 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.