STIMA-1 for cell activation

STIMA-1 (SH group-targeting compound that induces massive apoptosis) reactivates mutant p53. STIMA-1 can stimulate mutant p53 DNA binding in vitro and induce expression of p53 target proteins and trigger apoptosis in mutant p53-expressing human tumor cells. STIMA-1 is shown to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

N/A

91634-12-7

172.19

Biochemicals

2-Vinyl-4H-quinazolinol; SH group-targeting compound that induces massive apoptosis

C₁₀H₈N₂O

Off-white solid

N/A

No

Yes

≥97%

DMSO

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.