URMC-099 for cell activation
Catalog number
9443-5
Name
URMC-099 for cell activation
Size
5 mg
Price
175.00 EUR
Supplier
Details
Description
URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC₅₀ values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment reduces inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevents destruction and phagocytosis of cultured neuronal axons by these cells.
Peptide sequence
N/A
CAS number
1229582-33-5
Molecular weight
421.55
Category
Biochemicals
Other name
3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine
Molecular formula
C₂₇H₂₇N₅
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (~5 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
