CPI-613 for cell activation

Catalog number
9464-50
Name
CPI-613 for cell activation
Size
50 mg
Price
414.00 EUR
Supplier

Details

Description
CPI-613 is a non-redox active lipoate derivative that acts as a selective inhibitor mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. In vitro, CPI-613 dose-dependently and efficiently kills H460 human lung cancer cells and Saos-2 human sarcoma cells. In vitro, CPI-613 treatment potently disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity. CPI-613 treatment also leads to loss of mitochondrial membrane potential as assessed by JC-1 mitochondrial uptake. CPI-613 also induces apoptotic and non-apoptotic cell death in the cells of H460 human lung cancer and Saos-2 human sarcoma in vitro. 
Peptide sequence
N/A
CAS number
95809-78-2
Molecular weight
388.59
Category
Biochemicals
Other name
6,8-Bis[(phenylmethyl)thio]octanoic acid
Molecular formula
C₂₂H₂₈O₂S₂
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>30 mg/ml) or EtOH (>20 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.