PRIMA-1MET for cell activation
Catalog number
9485-5
Name
PRIMA-1MET for cell activation
Size
5 mg
Price
153.00 EUR
Supplier
Details
Description
PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 2170). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.
Peptide sequence
N/A
CAS number
5291-32-7
Molecular weight
199.25
Category
Biochemicals
Other name
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one; APR-246
Molecular formula
C₁₀H₁₇NO₃
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
N/A
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>15 mg/ml) or H₂O (>15 mg/ml)
Storage condition
-20°C
Shipping condition
Gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
