Ku-60019 for cell activation

Catalog number
9572-5
Name
Ku-60019 for cell activation
Size
5 mg
Price
153.00 EUR
Supplier

Details

Description
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
Peptide sequence
N/A
CAS number
925701-49-1
Molecular weight
547.67
Category
Biochemicals
Other name
(2R,​6S)​-2,​6-​dimethyl-​N-​[5-​[6-​(4-​morpholinyl)​-​4-​oxo-​4H-​pyran-​2-​yl]​-​9H-​thioxanthen-​2-​yl]​-​4-​morpholineacetamide
Molecular formula
C₃₀H₃₃N₃O₅S
Physical appearance
Light yellow to yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.