SBI-0206965 for cell activation
Catalog number
9580-25
Name
SBI-0206965 for cell activation
Size
25 mg
Price
588.00 EUR
Supplier
Details
Description
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965 suppresses ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergizes with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells.
Peptide sequence
N/A
CAS number
N/A
Molecular weight
489.33
Category
Biochemicals
Other name
2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Molecular formula
C₂₁H₂₁BrN₄O₅
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO >20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
