β-Glycyrrhetinic acid for cell activation
Catalog number
9586-1G
Name
β-Glycyrrhetinic acid for cell activation
Size
1 g
Price
121.00 EUR
Supplier
Details
Description
β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. It inhibits 15-PGDH (15-hydroxyprostaglandin dehydrogenase) leading to increased prostaglandin concentration in the digestive system. Displays anti-ulcerative, anti-inflammatory, and immunomodulatory properties. In addition, β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC₅₀ values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. Also protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 (NF-E2-related factor-2) and PPARγ.
Peptide sequence
N/A
CAS number
471-53-4
Molecular weight
470.68
Category
Biochemicals
Other name
3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid, Enoxolone; STX352; GM1658; NSC 35347
Molecular formula
C₃₀H₄₆O₄
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥97% by titration
Reconstitute instructions
DMSO (>15 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
