NMS-873 for cell activation
Catalog number
9600-25
Name
NMS-873 for cell activation
Size
25 mg
Price
545.00 EUR
Supplier
Details
Description
NMS-873 is a potent, selective, allosteric inhibitor of the ATPase VCP/p97 (IC₅₀ = 30 nM). NMS-873 activates the unfolded protein response, interferes with autophagy and induces cancer cell death. NMS-873 also inhibits proliferation of HCT116 cancer cell line cells with an IC₅₀ value of 400 nM.
Peptide sequence
N/A
CAS number
1418013-75-8
Molecular weight
520.67
Category
Biochemicals
Other name
(3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-pyridine
Molecular formula
C₂₇H₂₈N₄O₃S₂
Physical appearance
Off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>10 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
