Eeyarestatin I for cell activation

Eeyarestatin I is an inhibitor of the ERAD (Endoplasmic-reticulum -associated protein degradation) pathway, blocking the degradation of misfolded proteins at a dose of 8 µM. It associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3 (atx3).  Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the pro-apoptotic protein NOXA.

N/A

412960-54-4

630.44

Biochemicals

  3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

C₂₇H₂₅Cl₂N₇O₇

White to off-white solid

N/A

No

Yes

≥98% by HPLC

DMSO (>30 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.