MI-773 for cell activation
Catalog number
9610-5
Name
MI-773 for cell activation
Size
5 mg
Price
251.00 EUR
Supplier
Details
Description
MI-773, also known as SAR405838, is a spiro-oxindole that acts as a highly potent and selective MDM2 inhibitor. MI-773 binds to MDM2 with a Ki value of 0.88 nM and blocks the MDM2-p53 interaction. It activates wild-type p53 in vitro and in xenograft tumor tissue of leukemia and solid tumors, leading to p53-dependent cell cycle arrest and/or apoptosis.
Peptide sequence
N/A
CAS number
1303607-60-4
Molecular weight
562.51
Category
Biochemicals
Other name
(2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide
Molecular formula
C₂₉H₃₄Cl₂FN₃O₃
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
