U-104 for cell activation

U-104 is a ureido-sulfonamide inhibitor of transmembrane carbonic anhydrase IX (CAIX) (Ki = 45.1 nM) and XII (CAXII) (Ki = 4.5 nM). It displays weaker affinity for the cytosolic isoforms, CAI and CAII (Kis = 5.08 and 9.64 µM, respectively). U-104 associates with CAIX/CAXII only under hypoxic conditions in vivo, reducing extracellular acidity and resulting in significant inhibition of tumor growth and metastasis in experimental models.

N/A

178606-66-1

309.32

Biochemicals

1-(4-fluorophenyl)-3-(4-sulfamoylphenyl)urea; NSC-213841

C₁₃H₁₂FN₃O₃S

White solid

N/A

No

Yes

≥98% by HPLC

DMSO (>25 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.