JH-II-127 for cell activation

JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.

N/A

1700693-08-8 

416.87

Biochemicals

4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone

C₁₉H₂₁ClN₆O₃

Crystalline solid

N/A

No

Yes

≥98% by HPLC

DMSO (>20 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.