L-189 for cell activation

Catalog number
9674-5
Name
L-189 for cell activation
Size
5 mg
Price
153.00 EUR
Supplier

Details

Description
L-189 is a DNA ligase I, III and IV inhibitor (IC₅₀ values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki= 5 μM for DNA ligase I). L-189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L-189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
Peptide sequence
N/A
CAS number
64232-83-3
Molecular weight
246.29
Category
Biochemicals
Other name
(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Molecular formula
C₁₁H₁₀N₄OS
Physical appearance
White solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.