Orlistat for cell activation

Orlistat is a cell-permeable, selective, and competitive lipase inhibitor (IC₅₀ = 0.15 µM). Targets serine hydrolases in the nervous system, such as diacylglycerol lipase (DAGL), which is responsible for the conversion of DAG to 2-AG. Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat, promoting weight loss. Promotes the sensitivity to TRAIL in cancer cells by ROS-mediated pathways. Displays antiobesity and antihypercholesterolemic activity in vivo.

N/A

96829-58-2

495.73

Biochemicals

N-Formyl-L-leucine (1S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; Tetrahydrolipstatin

C₂₉H₅₃NO₅

White solid

N/A

No

Yes

≥98% by HPLC

DMSO

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.