MCC950 (Free base) for cell activation
Catalog number
B1031-5
Name
MCC950 (Free base) for cell activation
Size
5 mg
Price
458.00 EUR
Supplier
Details
Description
MCC950 is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
Peptide sequence
N/A
CAS number
210826-40-7
Molecular weight
404.48
Category
Biochemicals
Other name
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide; CP-456,773; CRID3
Molecular formula
C₂₀H₂₄N₂O₅S
Physical appearance
Light yellow to yellow solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>35 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
