PX-478 hydrochloride for cell activation
Catalog number
B1033-5
Name
PX-478 hydrochloride for cell activation
Size
5 mg
Price
197.00 EUR
Supplier
Details
Description
PX-478 hydrochloride is an inhibitor of HIF-1α (IC₅₀ of 20-30 μM) with potential antineoplastic activity. PX-478 inhibits HIF-1alpha protein levels and transactivation in a variety of cancer cell lines. The inhibitory effect of PX-478 on HIF-1alpha levels is primarily due to its inhibition of translation because HIF-1alpha translation continues in hypoxia when translation of most proteins is decreased.
Peptide sequence
N/A
CAS number
685898-44-6
Molecular weight
394.11
Category
Biochemicals
Other name
(S)-4-(2-amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
Molecular formula
C₁₃H₂₀Cl₄N₂O
Physical appearance
Brown solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
H₂O (> 5 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and moisture
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
