2-Deoxy-D-Glucose for cell activation

2-Deoxy-D-Glucose is a glucose analog that has long been known to act as a competitive inhibitor of glucose metabolism. Upon transport into the cells, 2-DG is phosphorylated by hexokinase to 2-DG-P. However, unlike G-6-P, 2-DG-P cannot be further metabolized by phosphohexose isomerase, which converts G-6-P to fructose-6-phosphate . 2-Deoxyglucose-P is trapped and accumulated in the cells, leading to inhibition of glycolysis mainly at the step of phosphorylation of glucose by hexokinase. Inhibition of this rate-limiting step by 2-DG causes a depletion of cellular ATP, leading to blockage of cell cycle progression and cell death in vitro.

N/A

154-17-6

164.16

Biochemicals

2-Deoxy-D-arabinohexose, 2-Deoxyglucose

C₆H₁₂O₅

White to off-white solid

N/A

No

Yes

≥98% GC

H2O (>15 mg/ml) or DMSO (>15 mg/ml)

+4°C

gel pack

36 months

Protect from air and moisture

cell

For cells, cell lines and tissues in culture till half confluency.