NSC-59984 for cell activation
Catalog number
B1052-25
Name
NSC-59984 for cell activation
Size
25 mg
Price
458.00 EUR
Supplier
Details
Description
NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than those of normal cells, with EC₅₀ of 8.38 μM for p53-null HCT116 cells. NSC-59984 induces p73-dependent cell apoptosis in cancer in vivo.
Peptide sequence
N/A
CAS number
803647-40-7
Molecular weight
265.27
Category
Biochemicals
Other name
(E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
Molecular formula
C₁₂H₅N₃O₄
Physical appearance
Crystalline solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
