5’-Deoxy-5’-methylthioadenosine for cell activation

5'-Deoxy-5'-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. Acts as a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.

N/A

2457-80-9

297.3

Biochemicals

5'-S-methyl-5'-thio-adenosine; Methylthioadenosine; MTA; NSC 335422; Vitamil L2

C₁₁H₁₅N₅O₃S

White to off-white solid

N/A

No

Yes

≥98%

DMSO (~25 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.