α-Mangostin for cell activation

α-Mangostin, a naturally occurring xanthone, displays both fast-binding and slow-binding inhibitions to FAS in vitro. It inhibits FAS overall reaction with an IC50 value of 5.54 μM noncompetitively with respect to NADPH, and partially competitively against both substrates acetyl-CoA and malonyl-CoA. Its inhibitory activity is higher than classical FAS inhibitors such as C75, EGCG and curcumin. It induces apoptosis in breast cancer cells by inhibition of FAS.

N/A

6147-11-1

410.46

Biochemicals

1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one; Mangostine

C₂₄H₂₆O₆

Pale yellow to yellow solid

N/A

No

Yes

≥95% by HPLC

DMSO (>50 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.