GW-0742 for cell activation

GW 0742 is a potent and selective PPARδ agonist (EC₅₀ = 1.1 nM) that displays 1,000-fold selectivity over other human PPAR subtypes. Therapeutically has shown to have effect on pulmonary damage, inflammatory and apoptotic parameters in mice. It increases the rate of fatty acid oxidation and provides ischemia /reperfusion injury protection in cardiomyocytes. It has been reported to have neuroprotective properties and enhances interleukin-6 (IL-6), IL-8 expression.

N/A

317318-84-6

471.49

Biochemicals

[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid

C₂₁H₁₇F₄NO₃S₂

White Solid

N/A

No

Yes

≥98% by HPLC

DMSO (>40 mg/ml)

-20°C

gel pack

36 months

Protect from air and light

cell

For cells, cell lines and tissues in culture till half confluency.