UMI-77 for cell activation
Catalog number
B1108-5
Name
UMI-77 for cell activation
Size
5 mg
Price
175.00 EUR
Supplier
Details
Description
UMI-77 is a novel, selective, Mcl-1 SMI inhibitor. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. It inhibits cell growth and induces apoptosis in pancreatic cancer cells.
Peptide sequence
N/A
CAS number
518303-20-3
Molecular weight
468.34
Category
Biochemicals
Other name
2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid
Molecular formula
C₁₈H₁₄BrNO₅S₂
Physical appearance
White to off-white solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>20 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
