WDR5 0103 for cell activation
Catalog number
B1125-50
Name
WDR5 0103 for cell activation
Size
50 mg
Price
632.00 EUR
Supplier
Details
Description
WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM). It inhibits the catalytic activity of MLL core complex in in vitro experiments with IC₅₀ of 39 µM. WDR5 is a component of mixed lineage leukemia (MLL) that targets histone-3 and in vitro data shows interaction of WDR5-0103 with MLL inhibits MLL core complex methyltransferase activity. However WDR5-0103 has no effect on other methyltransferases.
Peptide sequence
N/A
CAS number
890190-22-4
Molecular weight
383.44
Category
Biochemicals
Other name
3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
Molecular formula
C₂₁H₂₅N₃O₄
Physical appearance
White Solid
Supplied with
N/A
Is this a salt?
No
Is it cell-permeable?
Yes
Purification
≥98% by HPLC
Reconstitute instructions
DMSO (>35 mg/ml)
Storage condition
-20°C
Shipping condition
gel pack
Maximum time for storage
36 months
Storage instructions
Protect from air and light
Tissue
cell
Additional description
For cells, cell lines and tissues in culture till half confluency.
